We characterize science in terms of nihilism: the nihilism of science is something faced not in what science i mplies, but as the very essence of science as such. The nihilism of science is the birth of the truth of Nietzsche's announcement "God is dead" from within science as it must now face its repressed subjective core. But in truth, as the Psychoanalytic tradition has determined, it is subjectivity itself that is a bottomless searching-the subject is itself born from nothing. (...) In this way it becomes clear that the nihilism of science is in fact the birth of a nothingness as the essence of science insofar as it embraces the nothingness of its own subjectivity. Therefore, we show that the proper determination of the crisis of science is not made via phenomenology, as Husserl attempted in the early 20th century, but can only be made properly in a philosophical-psychoanalytic register. This nihilism is encoded within science in its very modality of thought , as Heidegger well understood: science thinks by means of "representation", and it is this "representational thinking" which prevents the expression of the repressed core of subjectivity. Therefore, by overcoming representation, it is seen that science will no longer be in despair to determine itself as a self, but come to see that this self, grounded in nothingness, in fact becomes its greatest and final expression, that is, as a self rooted not in an unending yearning for the transcendent certainty of a ground, but in a productive desire -self as will-to-create, will-to-power . This transition from the self as rooted in Desire qua lack to a self as determined by an infinitely productive desire is shown to be, in fact, the transition from Lacan to Deleuze. Once this transition is accomplished, it becomes clear that the anti-representational mode of thinking, accompanied by the productive self as will-to-power, determines science not from a transcendent metaphysic , but as an aesthetically determined modality of pure creativity-i.e., as an art . We then conclude by speculating on the proper form of art that this new science should take. We see that anti-representational thinking, rooted in the self as infinite creativity , is determined not by concepts, but by play or performances . Perhaps, then, we should consider music as determining the proper artistic form of this new kind of science? In this way we finally come to see the possibility for the first time of music as a new kind of science. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}. (shrink)

_Conservative Reductionism_ sets out a new theory of the relationship between physics and the special sciences within the framework of functionalism. It argues that it is wrong-headed to conceive an opposition between functional and physical properties and to build an anti-reductionist argument on multiple realization. By contrast, all properties that there are in the world, including the physical ones, are functional properties in the sense of being causal properties, and all true descriptions that the special sciences propose can in principle (...) be reduced to physical descriptions by means of functional reduction, despite multiple realization. The book develops arguments for from the metaphysics of properties and the philosophy of physics. These arguments lead to a conservative ontological reductionism. It then develops functional reduction into a fully-fledged, conservative theory reduction by means of introducing functional sub-types that are coextensive with physical types, illustrating that conservative reductionism by means of case studies from biology. (shrink)

A great deal of scholarly attention has been paid to coercion. Less attention has been paid to what might be a more pervasive form of influence: manipulation. The essays in this volume address this relative imbalance by focusing on manipulation, examining its nature, moral status, and its significance in personal and social life.

The sharing economy has transformed economic transactions, created new organizational forms, and contributed to changes in consumer culture. Started as a movement with promises of a more sustainable, democratic, and inclusive economy, the sharing economy, and its impact on issues such as privacy, discrimination, worker rights, and regulation, is now the subject of heated debate. Many of these issues root in the changes that digital technologies have brought and the unresolved moral and ethical questions emerging therefrom. This special issue contributes (...) to this ongoing debate with five articles that develop theoretical frameworks and conduct empirical investigations, providing fine-grained analyses of urgent issues in the sharing economy. In this article, we highlight these and other issues that we believe deserve further attention from business ethics scholarship. (shrink)

Der Klimawandel ist die globale Krise unserer Gegenwart. Mit Blick auf die sich hieraus ergebenen Handlungsoptionen und -zwänge stellt der verantwortliche Umgang mit Energie sicher einen der zentralen Bereiche dar. Unsere ethische Verantwortung betrifft dabei beides: Erzeugung und Verbrauch von Energie gleichermaßen. Der vorliegende Band verfolgt zwei Ziele: Erstens soll ein interdisziplinärer Dialog ermöglicht und die dafür notwendigen fachlichen Reflexionen angestoßen werden. Keine Einzeldisziplin kann auf die komplexen Probleme des Klimawandels oder die mit dem Terminus Energieverantwortung angezeigten Herausforderungen alleine eine (...) plausible Antwort geben. Vielmehr müssen die Wissenschaften ein gemeinsames Verständnis der Probleme entwickeln, um auch interdisziplinär geteilte Antworten bereitstellen zu können. Zweitens soll dies in transdisziplinärer Perspektive erfolgen. Das bedeutet, die von der Gesellschaft an die Wissenschaft herangetragenen Fragen und Problemstellungen ernst zu nehmen, aufzugreifen und Antworten zu formulieren, die auch außerhalb der wissenschaftlichen Diskurse als Antworten auf diese Fragen und Problemstellungen verstanden werden können. (shrink)

Der Band widmet sich der Frage, wer verantwortlich ist für einen ethisch angemessenen Umgang mit Energie. Dazu sollen zunächst im ersten Teil die normativen Grundlagen von Energieverantwortung skizziert werden. Im zweiten Teil werden mögliche Spannungsfelder identifiziert, die in verschiedenen gesellschaftlichen, wirtschaftlichen und politischen Dimensionen bestehen. Im abschließenden dritten Teil wird die Perspektive auf Probleme erweitert, die durch die Implementierung energieverantwortlicher Maßnahmen und Bestrebungen entstehen. So leistet der Band eine Ordnung der Fragen rund um Energieverantwortung sowie die Darstellung, Bewertung und Lösung (...) konkreter Handlungsprobleme im Feld der Energie-Nachhaltigkeit. (shrink)

As a contribution to current debates on the ‘social life of methods’, in this article we present an ethnomethodological study of the role of understanding within statistical practice. After reviewing the empirical turn in the methods literature and the challenges to the qualitative-quantitative divide it has given rise to, we argue such case studies are relevant because they enable us to see different ways in which ‘methods’, here quantitative methods, come to have a social life – by embodying and exhibiting (...) understanding they ‘make the social structures of everyday activities observable’ ( Garfinkel, 1967 : 75), thereby putting society on display. Exhibited understandings rest on distinctive lines of practical social and cultural inquiry – ethnographic ‘forays’ into the worlds of the producers and users of statistics – which are central to good statistical work but are not themselves quantitative. In highlighting these non-statistical forms of social and cultural inquiry at work in statistical practice, our case study is an addition to understandings of statistics and usefully points to ways in which studies of the social life of methods might be further developed from here. (shrink)

The goal of this article is to outline a new account of the virtue of patience. To help build the account, we focus on five important issues pertaining to patience: (i) goals and time, (ii) emotion, (iii) continence versus virtue, (iv) motivation, and (v) good ends. The heart of the resulting account is that patience is a cross-situational and stable disposition to react, both internally and externally, to slower than desired progress toward goal achievement with a reasonable level of calmness. (...) The article ends with an application of the account to better understanding the vices associated with patience. (shrink)

Some of the required characteristics for a true machine theory of mind (MToM) include the ability to (1) reproduce the full diversity of human thought and behavior, (2) develop a personalized model of an individual with very limited data, and (3) provide an explanation for behavioral predictions grounded in the cognitive processes of the individual. We propose that a certain class of cognitive models provide an approach that is well suited to meeting those requirements. Being grounded in a mechanistic framework (...) like a cognitive architecture such as ACT-R naturally fulfills the third requirement by mapping behavior to cognitive mechanisms. Exploiting a modeling paradigm such as instance-based learning accounts for the first requirement by reflecting variations in individual experience into a diversity of behavior. Mechanisms such as knowledge tracing and model tracing allow a specific run of the cognitive model to be aligned with a given individual behavior trace, fulfilling the second requirement. We illustrate these principles with a cognitive model of decision-making in a search and rescue task in the Minecraft simulation environment. We demonstrate that cognitive models personalized to individual human players can provide the MToM capability to optimize artificial intelligence agents by diagnosing the underlying causes of observed human behavior, projecting the future effects of potential interventions, and managing the adaptive process of shaping human behavior. Examples of the inputs provided by such analytic cognitive agents include predictions of cognitive load, probability of error, estimates of player self-efficacy, and trust calibration. Finally, we discuss implications for future research and applications to collective human–machine intelligence. (shrink)

Humean Laws for Human Agents presents cutting-edge research by leading experts on the Humean account of laws, chance, possibility, and necessity. A central question in metaphysics and philosophy of science is: What are laws of nature? Humeans hold that laws are not sui generis metaphysical entities but merely particularly effective summaries of what actually happens. The most discussed recent work on Humeanism emphasizes the laws' usefulness for limited agents and uses pragmatic considerations to address fundamental and long-standing problems. The current (...) volume develops and critically examines pragmatic Humean accounts, with innovative new work on the epistemology of laws and chance, the problem of induction, counterfactuals, special science laws, and a Humean account of essence. Taken together, the papers provide a roadmap for developing pragmatic Humeanism and connate views, setting the agenda for future research. (shrink)

The rapid evolution of drug resistance remains a major obstacle for HIV therapy. The capacity of the virus for recombination is widely believed to facilitate the evolution of drug resistance. Here, we challenge this intuitive view. We develop a population genetic model of HIV replication that incorporates the processes of mutation, cellular superinfection, and recombination. We show that cellular superinfection increases the abundance of low fitness viruses at the expense of the fittest strains due to the mixing of viral proteins (...) during virion assembly. Moreover, we argue that whether recombination facilitates the evolution of drug resistance depends critically on how resistance mutations interact to determine viral fitness. Contrary to the commonly held belief, we find that, under the most plausible biological assumptions, recombination is expected to slow down the rate of evolution of multi‐drug‐resistant virus during therapy. BioEssays 26:180–188, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Translating Religion advances thinking about translation as a critical category in religious studies, combining theoretical reflection about processes of translation in religion with focused case studies that are international, interdisciplinary, and interreligious. By operating with broad conceptions of both religion and translation, this volume makes clear that processes of translation, broadly construed, are everywhere in both religious life and the study of religion; at the same time, the theory and practice of translation and the advancement of translation studies as a (...) field has developed in the context of concerns about the possibility and propriety of translating religious texts. The nature of religions as living historical traditions depends on the translation of religion from the past into the present. Interreligious dialogue and the comparative study of religion require the translation of religion from one tradition to another. Understanding the historical diffusion of the world's religions requires coming to terms with the success and failure of translating a religion from one cultural context into another. Contributors ask what it means to translate religion, both textually and conceptually, and how the translation of religious content might differ from the translation of other aspects of human culture. This volume proposes that questions on the nature of translation find particularly acute expression in the domains of religion, and argues that theoretical approaches from translation studies can be fruitfully brought to bear on contemporary religious studies. (shrink)

Is it allowable for your government, or anyone else, to influence or coerce you 'for your own sake'? This is a question about paternalism, or interference with a person's liberty or autonomy with the intention of promoting their good or averting harm, which has created considerable controversy at least since John Stuart Mill's On Liberty. Mill famously decried paternalism of any kind, whether carried out by private individuals or the state. In this volume of new essays, leading moral, political and (...) legal philosophers address how to define paternalism, its justification, and the implications for public policy, professional ethics and criminal law. So-called 'libertarian' or non-coercive paternalism receives considerable attention. The discussion addresses the nature of freedom and autonomy and the relation of individuals to law, policy and the state. The volume will interest a wide range of readers in political philosophy, public policy and the philosophy of law. (shrink)

Erfüllen gewachsene Demokratien in der industrialisierten Welt das Versprechen einer Volksherrschaft oder stehen sie unter dem Einfluss einer Elite aus Politik und Wirtschaft? Von dieser Frage ausgehend entwickelt die vorliegende Monographie ein Demokratiemodell, das sich auf das Verhältnis zwischen Macht und Ohnmacht in der Gesellschaft bezieht und darauf eine moralische Verpflichtung in der Politik zurückführt. Der Text untersucht, unter welchen Bedingungen in Demokratien die individuelle Autonomie und Selbstbestimmung maximiert und die Androhung und Anwendung von Gewalt minimiert werden kann. Im Zentrum (...) steht die kritische Auseinandersetzung mit dem von Jürgen Habermas mitbegründeten Modell der deliberativen Demokratie. Der Autor entwickelt dazu ein alternatives Demokratiemodell, das aus einer pragmatischen Sichtweise die historischen und sozialen Ungleichheiten in der Gesellschaft berücksichtigt. Dies setzt allerdings eine kritische Auseinandersetzung mit den von Habermas entwickelten Grundbegriffen der kommunikativen Vernunft, der kommunikativen Rationalität und des kommunikativen Handelns voraus. (shrink)

Steve Paulson, executive producer and host of To the Best of Our Knowledge, moderated a discussion with philosopher Christian Miller, neuroscientist Heather Berlin, and historian of science Michael Shermer to examine our moral ecology and its influence on our underlying assumptions about human nature.

The Politics of the Texbook analyzes the factors that shape production, distribution and reception of school texts through original essays which emphasize the double-edged quality of textbooks. Textbooks are viewed as systems of moral regulation in the struggle of powerful groups to build political and cultural accord. They are also regarded as the site of popular resistance around discloding the interest underlying schoolknowledge and incorporating alternative traditions.

A central question in the philosophy of science is: What is a law of nature? Different answers to this question define an important schism: Humeans, in the wake of David Hume, hold that the laws of nature are nothing over and above what actually happens and reject irreducible facts about natural modality (Lewis, 1983, 1994; cf. Miller, 2015). According to Non-Humeans, by contrast, the laws are metaphysically fundamental (Maudlin, 2007) or grounded in primitive modal structures, such as dispositional essences of (...) powerful properties (Bird, 2007), necessitation relations (Armstrong, 1983), or primitive subjunctive facts (Lange, 2009). This volume focuses on recent developments in the discussion of Humeanism, specifically on pragmatic versions of the view that put the needs of limited agents like us front and center. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

Unter ‚Akzeptabilität‘ versteht man einerseits „gerechtfertigte Akzeptanzfähigkeit“ und andererseits „intersubjektive Angemessenheit“; Letztere wird in diesem Beitrag als praktische Kohärenz und soziale Verhältnismäßigkeit gefasst. Damit stellt das Konzept ethischer Akzeptabilität ein Angebot der praktischen Philosophie für den gesellschaftlichen Diskurs zur Akzeptabilitätsüberprüfung bereit. Als kritische Reflexionsinstanz geht es der Philosophie dabei weder um Akzeptanzbeschaffung noch um die Ermittlung möglicher oder erwartbarer Akzeptanz. Philosophische Politikberatung fokussiert als Ethik auf die Qualität der Gründe von Handlungen oder Handlungszielen von politischen Institutionen oder Personen.

Background:To date, most research on aggression in mental disorders focused on active-aggressive behavior and found self-directed and other-directed active aggression to be a symptom and risk-factor of psychopathology. On the other hand, passive-aggressive behavior has been investigated less frequently and only in research on psychodynamic defense mechanisms, personality disorders, and dysfunctional self-control processes. This small number of studies primarily reflects a lack of a reliable and valid clinical assessment of passive-aggressive behavior. To address this gap, we developed the Test of (...) Passive Aggression (TPA), a 24-item self-rating scale for the assessment of self-directed and other-directed passive-aggressive behavior.Method:Study 1 examined the internal consistency and factorial validity of the TPA in an inpatient sample (N= 307). Study 2 investigated the retest-reliability, internal consistency, and construct validity (active aggression, personality traits, impulsivity) of the TPA in a student sample (N= 180).Results:In line with our hypothesis, Exploratory Structural Equation Modeling revealed an acceptable to good fit of a bi-factorial structure of the TPA (Chi-square-df-ratio= 1.98;RMSR= 0.05, fit.off = 0.96). Both TPA scales showed good to excellent internal consistency (α= 0.83–0.90) and 4-week retest-reliability (rtt= 0.86). Correlations with well-established aggression scales, measures of personality, and impulsivity support discriminant and convergent validity of the TPA.Conclusions:The TPA is a reliable and valid instrument for the assessment of self-directed and other-directed passive-aggressive behavior. (shrink)

This paper points out the merit of Nagelian reduction, namely to propose a model of inter-theoretic reduction that retains the scientific quality of the reduced theory and the merit of functional reduction, namely to take multiple realization into account and to offer reductive explanations. By considering Lewis and Kim’s proposal for local reductions, we establish that functional reduction fails to achieve a theory reduction and cannot retain the scientific quality of the reduced theory. We improve on that proposal by showing (...) how one can build functional sub-types that are coextensive with physical realizer types and thereby obtain a theory reduction that is explanatory and that vindicates the scientific quality of the special sciences. (shrink)

The fifteen new essays collected in this volume address questions concerning the ethics of self-defense, most centrally when and to what extent the use of defensive force, especially lethal force, can be justified. Scholarly interest in this topic reflects public concern stemming from controversial cases of the use of force by police, and military force exercised in the name of defending against transnational terrorism. The contributors pay special attention to determining when a threat is liable to defensive harm, though doubts (...) about this emphasis are also raised. The legitimacy of so-called "stand your ground" policies and laws is also addressed. This volume will be of great interest to readers in moral, political, and legal philosophy. (shrink)

According to physicalism, everything is physical or metaphysically connected to the physical. If physicalism were true, it seems that we should – in principle – be able to reduce the descriptions and explanations of special sciences to physical ones, for example, explaining biological regularities, via chemistry, by the laws of particle physics. The multiple realization of the property types of the special sciences is often seen to be an obstacle to such epistemic reductions. Here, we introduce another, new argument against (...) epistemic reduction. Based on mathematical complexity, we show that, under certain conditions, there can be “complexity barriers” that make epistemic reduction – in principle – unachievable even if physicalism were true. (shrink)

In an increasingly data-driven age of medicine, do companies that offer genetic testing directly to patients represent an important part of personalising care, or a dangerous threat to privacy? Should we celebrate this new mechanism of patient involvement, or fear its implications?The Universities of Oxford and Cambridge addressed these issues in the 10th annual Medical Ethics Varsity Debate, through the motion: “This House Regrets the Rise of Direct-to-Consumer Genetic Testing”. This article summarises and extends key arguments made in the debate, (...) exploring the impacts of such genetic testing on both the individual patient and broader society, with special consideration as to whether companies can ever truly guarantee anonymity of genetic data. (shrink)

This paper sheds light on the possibilities and perspectives of linking digital editions of Medieval German texts to each other and to other digital resources. Furthermore, it discusses some of the internal and technical conditions necessary to render this linkage meaningful, like lemmatisation, part-of-speech-tagging, and using standardised mark-up languages. Finally, the sustainability and reusability of digital editions are considered. While in the past, editions of medieval texts were conceived as rather isolated scholarly works of individual editors, nowadays the collaboration and (...) cooperation of greater working groups is essential in editing projects. Due to the complexity of editions consisting of multiple textual layers, e. g. apparatus entries, annotations, or facsimiles, the requirements for future digital editions have risen. The first approach to respond to these demands is to link the various textual layers to each other, enabling the users to navigate between these layers in a sensible way. The second step is to link the edited text to other resources, such as online dictionaries or other editions, allowing complex research networks to be created. These goals are achieved by lemmatising and other tagging methods, ensuring the information being mapped to a normalised and idealised frame of reference. Common standards like Unicode or the TEI guidelines are of great importance for such purposes, as they assure the interchange and re-use of scientific data, as well as their sustainability. (shrink)

This paper examines the critical role that organizational leaders play in establishing a values based climate. We discuss seven mechanisms by which leaders convey the importance of ethical values to members, and establish the expectations regarding ethical conduct that become engrained in the organizations climate. We also suggest that leaders at different organizational levels rely on different mechanisms to transmit values and expectations. These mechanisms then influence members practices and expectations, further increase the salience of ethical values and result in (...) the shared perceptions that form the organizations climate. The paper is organized in three parts. Part onebegins with a brief discussion of climates regarding ethics and the critical role of values. Part two provides discussion on the mechanisms by which leaders and members transmit values and create climates related to ethics. Part three provides a discussion of these concepts with implications for theory, research, and practice. (shrink)

The use of evidence in medicine is something we should continuously seek to improve. This book seeks to develop our understanding of evidence of mechanism in evaluating evidence in medicine, public health, and social care; and also offers tools to help implement improved assessment of evidence of mechanism in practice. In this way, the book offers a bridge between more theoretical and conceptual insights and worries about evidence of mechanism and practical means to fit the results into evidence assessment procedures.

Grill (2023) defends the sum of averages view (SAV), on which the value of a population is found by summing the average welfare of each generation or birth cohort. A major advantage of SAV, according to Grill, is that it escapes the Egyptology objection to average utilitarianism. But, we argue, SAV escapes only the most literal understanding of this objection, since it still allows the value of adding a life to depend on facts about other, intuitively irrelevant lives. Moreover, SAV (...) has a decisive drawback not shared with either average or total utilitarianism: it can evaluate an outcome in which every individual is worse off as better overall, even when exactly the same people exist in both outcomes. These problems, we argue, afflict not only Grill's view but any view that uses a sum of subpopulation averages, apart from the limiting cases of average and total utilitarianism. (shrink)

This introductory chapter has several relatively modest aims, all in the service of preparing readers for the substantive chapters in the volume. First, we provide a basic summary of the contours of debate about the ethics of self-defense. In so doing, we highlight and explain some of the central terms in the debate, as there is a complex, specialized vocabulary that may be unfamiliar to some readers. Second, we distinguish and discuss the different contexts in which the need for self-defense (...) might arise. Third, we describe and briefly discuss how the discussion of the ethics of self-defense is typically carried out—the predominant methodology employed by the authors in this volume. (shrink)

Many physicalists are vague about how defining‘physical property’fits in with characterizing physicalism. We determine the proper relation of these tasks. Employing panpsychism as a yardstick, we argue that defining‘physical property’and characterizing physicalism are subject to contradictory conditions of adequacy. We conclude that these tasks should be kept neatly apart. Exploiting this insight, we save physicalists from an apparently disastrous anti‐physicalist argument, we propose and defend a viable definition of‘physical property’, and we argue that the standard characterization of physicalism is flawed. (...) We propose an improved account. (shrink)